Inventor Mark Kokoris on Roche’s New Sequencing by Expansion скачать в хорошем качестве

Inventor Mark Kokoris on Roche’s New Sequencing by Expansion

The biggest story in sequencing this year. Roche has unveiled a new sequencing chemistry that turns a human genome around in under four hours. It’s called Sequencing by Expansion (SBX)—and it’s unlike anything the field has seen. Mendelspod sat down with Mark Kokoris, the inventor of SBX and head of the program at Roche, to talk about how he got here, how it works, and why it matters. As Mark told us, “Our approach to efficiently sequencing DNA is to not sequence DNA. We rescale the problem—expand the molecule so we can read it with higher signal-to-noise.” 0:00 A long journey inspired by PCR 7:20 What is sequencing by expansion? 14:00 On scale and accuracy 19:40 Multi-omics vision? 24:40 What will be the killer app? 30:00 Biggest challenge for launch