У нас вы можете посмотреть бесплатно David Klatzmann, Sorbonne University & Pitié-Salpêtrière Hospital, Paris или скачать в максимальном доступном качестве, видео которое было загружено на ютуб. Для загрузки выберите вариант из формы ниже:
Если кнопки скачивания не
загрузились
НАЖМИТЕ ЗДЕСЬ или обновите страницу
Если возникают проблемы со скачиванием видео, пожалуйста напишите в поддержку по адресу внизу
страницы.
Спасибо за использование сервиса ClipSaver.ru
On the specificity of the T cell immune response tight & fuzzy Talk Abstract David Klatzman's talk challenges the classical view of T cell specificity by highlighting evidence for “diffuse” specificity in adaptive immunity. Despite the traditional idea that T cells are highly specific for particular pathogens, studies show that even a very limited repertoire of T cell receptors (TCRs) can protect against many infections, and that memory phenotype T cells can exist in individuals without prior exposure to the corresponding antigen. Klatzman emphasizes the concept of cross-reactivity, whereby a single TCR can recognize multiple different peptides due to molecular mimicry, suggesting that T cell responses are broader and more flexible than implied by the classic “lock and key” model. This broader specificity helps explain phenomena such as heterologous immunity, in which immunity to one pathogen influences the response to unrelated infections. Speaker Bio David Klatzmann is a Professor of Immunology at Sorbonne Université and Head of Biotherapy at Pitié-Salpêtrière Hospital, where he also coordinates the Inflammation-Immunopathology-Biotherapy Department. He earned his MD and PhD from Pierre & Marie Curie University, and has dedicated his career to advancing translational immunology. Klatzmann co-discovered HIV and identified CD4 as its primary receptor, pioneering critical insights into the pathogenesis of AIDS. His research has shaped innovative therapeutic approaches, including the development of suicide genes and low-dose IL-2 treatments for autoimmune diseases. He is particularly focused on regulatory T cells (Tregs), their antigen receptors, and their role in autoimmunity, cancer, and maternal-fetal tolerance. His work bridges basic immunology, systems biology, and clinical application, aiming to develop targeted biotherapies and inform precision medicine.