5. Statins (Part-1): Pharmacology Video Lectures USMLE Step 1 скачать в хорошем качестве

5. Statins (Part-1): Pharmacology Video Lectures USMLE Step 1

📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash 5. Statins (Part-1): Pharmacology Video Lectures ------------------------------------------------------------------------------- Statins are first-line lipid-lowering agents that competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, effectively reducing hepatic cholesterol production, upregulating LDL receptors, and increasing the clearance of LDL-C ("bad cholesterol") from the bloodstream 🩸🧬. Commonly prescribed statins include Atorvastatin, Rosuvastatin, Simvastatin, Pravastatin, and Lovastatin, each varying in potency, half-life, and lipophilicity 💊🚀. High-intensity statin therapy (e.g., Atorvastatin 40–80 mg or Rosuvastatin 20–40 mg) can lower LDL-C by ≥50%, markedly reducing the risk of atherosclerotic cardiovascular disease (ASCVD), myocardial infarction, and stroke 🏥💖. Moderate-intensity regimens (e.g., Simvastatin 20–40 mg, Pravastatin 40–80 mg) are often chosen for patients with lower-risk profiles or those who cannot tolerate higher doses 🌍⚠️. Beyond LDL reduction, statins stabilize atherosclerotic plaques, reduce inflammation, and improve endothelial function, further decreasing cardiovascular events 🏆🔬. While generally well-tolerated, adverse effects can include myalgia, elevated hepatic enzymes, and in rare cases, rhabdomyolysis, warranting liver function tests (LFTs) and creatine kinase (CK) monitoring, particularly at higher doses ⚠️🩺. Patients should be educated about potential drug interactions (especially with CYP3A4 inhibitors for Simvastatin/Lovastatin) and advised to report unexplained muscle pain or weakness promptly 🚨💢. Combining statins with other lipid-lowering agents (e.g., ezetimibe, bile acid sequestrants, PCSK9 inhibitors) can achieve additional LDL reductions for high-risk or familial hypercholesterolemia patients 🦠🛡️. Ultimately, dietary modifications, regular exercise, weight management, and smoking cessation synergize with statin therapy to promote optimal cardiovascular outcomes 🌎💓. #statins #HMGCoAReductaseInhibitors #LDLCholesterol #Atherosclerosis #HeartHealth #Pharmacology #Dyslipidemia #Atorvastatin #Rosuvastatin #Simvastatin #ASCVD #MedicalScience #USMLE #NEETPG #GlobalHealth #SaveHearts #CardiacCare #RationalDrugUse #medicalanimations #fmge #fmgevideos #rapidrevisionfmge #fmge2024 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2025 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #usmlestep2videos