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Discover why “bad” gut methane may be your body’s secret weapon for fixing broken methylation and detox pathways. Ever been told your “methane SIBO” or MTHFR mutation means you can’t methylate? Dr. Greg Nigh reveals how methane-producing gut microbes, deuterium depletion, and the folate cycle actually work together to protect your detox, DNA, and energy systems. Learn why simply killing methane bugs can backfire—and what really drives TMAO, glutathione, and homocysteine imbalances. 👉 Ready for personalized integrative care? Schedule a consult: https://gregnigh.com/schedule 🔔 Subscribe for weekly deep dives on Lyme, mold toxicity, SIBO, long COVID, integrative oncology & more. Like, share, and leave your questions below! CHAPTERS 00:00 – Introduction: Methylation, MTHFR & Methane SIBO 02:45 – How Bodies Create Symptoms to Solve Problems 05:13 – Classic Methylation Cycle (SAMe, Homocysteine, BHMT, MTHFR) 05:16 – Methane’s Role and Enzymatic Reactions with High KIE 05:55 – Deuterium Basics & Its Toxicity in Cells 08:15 – Gut Pathway: Hydrogen Gas → Methane → Formaldehyde 11:00 – Activation via Tetrahydrofolate / Methylene-THF 12:28 – Liver & Gut Methylation Interplay; Diet & Deuterium Load 14:20 – Choline Pathway: TMA, TMAO & Cardiovascular Links 17:30 – Why Killing Gut Methane Might Backfire 18:11 – Wrap-up & What’s Next Like ★ Subscribe ★ Share — join the Deep Dive community! Takeaways: • Methane gas can supply deuterium-depleted methyl groups critical for detox and gene regulation. • Excess TMAO is a downstream sign of failed deuterium scrubbing—not just high meat intake. • Blanket antibiotic or herb-kill approaches to methane SIBO may worsen methylation issues. • Supporting gut-liver synergy, low-deuterium strategies, and targeted nutrients beats bug-hunting. RESOURCES & LINKS • Deuterium 101 video: • Deuterium Explained: The Hidden Factor in ... • Previous SIBO gas episode: • SIBO Overview: Understanding Small Intesti... • Dr Nigh’s clinic & articles: https://gregnigh.com/ • Research paper preprint (methane & methylation): [link] CONNECT • Subscribe for more Deep Dive episodes: [channel link] • Facebook: / gregnighnaturopathicdoctor • X: https://x.com/gnigh • Podcast feed: / @drgregnigh DISCLAIMER This content is for educational purposes and is not medical advice. #SIBO #Methane #Methylation #GutHealth #DrGregNigh