7,12-dimethylbenzaanthracene скачать в хорошем качестве

7,12-dimethylbenzaanthracene

(DMBA) A polycyclic aromatic hydrocarbon, immunosuppressor, and powerful organ-specific laboratory carcinogen. It is and widely used in many research laboratories studying cancer. It serves as a tumor initiator. It is cytotoxic in nature and can cause selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors. Anthracene is a solid polycyclic aromatic hydrocarbon consisting of 3 fused benzene rings. It is a component of coal-tar and classified as noncarcinogenic. However, in contaminated aquatic environments, its photo-induced toxic response is aggravated by sunlight, that may represent a significant environmental hazard of polycyclic aromatic hydrocarbons in nature. The carcinogenic organic pollutant is generated from the incomplete combustion of gasoline and coal. (Where to be found) • tobacco smoke • diesel exhaust (Metabolic pathway) 1. DMBA-3,4-epoxide (intermediate) by cytochrome P450 (CYP 450) isoform 1B1 2. DMBA-3,4-diol hydrolyzed by microsomal epoxide hydrolase (mEH) 3. DMBA-3,4-diol-1,2-epoxide (carcinogenic and ovotoxic metabolite) by either CYP 1B1 or 1A1 (Examples of activities and diseases caused by this) • breast cancer: It increases proliferation and migration, inducing epithelial-to-mesenchymal transition. • mammary gland tumors in rats: After intragastric administration. • papilloma formation in a rat two-stage model of skin carcinogenesis: In combination with phorbol 12-myristate 13-acetate (TPA). • immunosuppressant activity: It inhibits proliferation of isolated mouse splenic B and T cells stimulated ex vivo with lipopolysaccharide or concanavalin A.