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Book recommendations involving insulin & diabetes Insulin: the crooked timber: a history from thick brown muck to Wall Street gold by Kersten T. Hall, 2022 If you’re anticipating a book about insulin, you might get more than you bargained for. Turns out, this book is a very wide-reaching science history book – covering topics such as early protein biochemistry, the birth of molecular biology, the genesis of biotech, and pharmaceutical shenanigans. A great read for science history buffs, but definitely not what I was expecting, so know what you’re getting yourself into! (And it’ll help if you have a biochemistry and/or molecular biology background already) Told in 3 parts: 1) Discovery of insulin – you might have heard of Banting & Best, perhaps even their feud with Macleod and Collip, but it actually turns out it’s way more complicated and there were others before them 2) Discovery of the nature of insulin – Fred Sanger figuring out its sequence, Dorothy Crowfoot Hodgkin solving its structure, etc. 3) Development of insulin as a pharmaceutical product – birth of biotech, development of different “designer” insulin, controversies over price, etc. Insulin: A Hundred-Year History by Stuart Bradwel, 2023 A much more accessible book than Hall’s “Insulin: the crooked timber” Rather than focusing on the scientific discovery of insulin, it takes a patient’s perspective and covers diabetes treatment over time more broadly from more of a sociological perspective Criticizes paternalistic treatment of people with diabetes over time Takes a critical view of expensive “improved” versions of insulin while patients struggle to access &/or afford even the basic form Takes on the incredible injustices in insulin (in)accessibility Fred Sanger – Double Nobel Laureate by George G. Brownlee, 2014 Comprehensive biography from one of Sanger’s trainees that’s heavy on the science (just like I like it!) It includes extensive interviews with Fred Sanger and lots of great pictures and figures taking you through the development of Sanger sequencing (for DNA, RNA, and proteins – including, first and foremost, insulin!). It also includes reminiscences by colleagues and peers. Dorothy Crowfoot Hodgkin: Patterns, Proteins and Peace: A Life in Science by Georgina Ferry, 2014/2020 (Updated version) The life story of one of my all-time favorite scientists, pioneering x-ray crystallographer and peace activist Dorothy Crowfoot Hodgkin who won the Nobel Prize in 1964 for solving the structure of vitamin-B12 (which required playing a significant role in developing crystallographic methods). Her real goal, however, was insulin, and she solved its structure (after years of wrangling with it) in 1969. The author does a great job of incorporating Dorothy’s own recollections, diary entries, etc. so you really feel like you get to know her as a person as well as a scientist. After doing so, she seems more awe-inspiring as a scientist, while at the same time also much more human. The book also gives a great behind-the-scenes of the early days of x-ray crystallography. It’s pretty hard-core on the science, but I highly recommend it for anyone interested in structural biology, especially! More on Crowfoot Hodgkin: http://bit.ly/dorothycrowfoothodgkin more recommendations for things to read, watch, & listen to; https://www.youtube.com/playlist?list... Blog version: https://bit.ly/bbbookrecs Doc: https://docs.google.com/document/d/1v... more about all sorts of things: #365DaysOfScience All (with topics listed) 👉 http://bit.ly/2OllAB0 or search blog: http://thebumblingbiochemist.com #biochemistry #molecularbiology #biology #sciencelife #science #realtimechem