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Dr. Rui Wang, a member of the Department of Biology and the vice-president of research at Laurentian University, speaks about the discovery and physiological importance of hydrogen sulfide. With its repulsive odor, H2S appears to be nothing but a noxious “rotten-egg” gas. Quite contrary to this conventional notion, our bodies in fact produce H2S and we are what we smell. In this talk, I will highlight some most promising and intriguing discoveries in H2S biology and medicine, including the endogenous production of H2S in the vascular system, catalized by catalysed by cystathionine gamma-lyase (CSE). I will also address on the roles of H2S in the regulation of blood pressure and endothelium-dependent vasorelaxation, differential regulation of cell proliferation, ion channel functions, and mitochondrial bioenergetics. Collectively, the ability of the CSE/H2S pathway to regulate the cardiovascular functions suggests that that the smelly hydrogen sulfide gas is so critical to our health that we cannot live without it.