CaAKG - the healthspan extender you need to know about? скачать в хорошем качестве

CaAKG - the healthspan extender you need to know about?

Alpha-ketoglutarate (AKG) is a small compound, but plays a big role in our cells. Notably, AKG is a key component in the metabolic pathway, the Krebs Cycle. However, levels of AKG have been shown to decline with age. Delivered as a calcium salt (CaAKG), this recent publication (ref below) shows that AKG can extend healthspan in both male and female mice, and extends lifespan in middle-aged female mice. In this video, I will discuss in more detail what AKG is, the results of this paper and my thoughts. TIMESTAMPS; 00:00 - Intro 00:56 - What is AKG? Aging connection 04:27 - Study results 08:35 - How/Why AKG has this effect? 10:00 - AKG in humans? 11:00 - Thoughts/Outlook **reference at 3:42 should be https://doi.org/10.1111/acel.13059 Aging Cell. 2020;19:e13059 !! REFERENCES; Paper -- Asadi Shahmirzadi et al., 2020, Cell Metabolism 32, 447–456 September 1, 2020 ª 2020 Published by Elsevier Inc. https://doi.org/10.1016/j.cmet.2020.0... Press Release - https://www.lifespan.io/news/pilot-st... & https://pdlhealth.com/in-the-news/ Dr Kennedy Lab; https://www.buckinstitute.org/lab/ken... Extends lifespan in C.elegans; Chin, R., Fu, X., Pai, M. et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510, 397–401 (2014). https://doi.org/10.1038/nature13264 Pigs; Oncotarget. 2017; 8:91965-91978. https://doi.org/10.18632/oncotarget.2... Gut Microbiome - The effects of dietary supplementation with α-ketoglutarate on the intestinal microbiota, metabolic profiles, and ammonia levels in growing pigs https://doi.org/10.1016/j.anifeedsci.... I use Brave browser, check it out and download for free and earn BAT for browsing: https://brave.com/jaw125 Icons in intro; "https://www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com