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Fuchs dystrophy is now effectively curable, thanks to modern advances in corneal surgery. Today, the endothelial layer of the cornea can be selectively replaced. There are two strategies to achieve this goal, represented by two different surgeries. DSAEK: This surgery was invented in 1998 in Holland and proved, for the first time, that it was technically possible to replace only the patient’s dysfunctional endothelium, without performing a full corneal transplant. Although this operation is now more than 20 years old, the procedure has a strong track record of success. DMEK: This surgery was invented in the 2000’s, specifically as a modern upgrade of DSAEK. It is specifically designed to be less invasive and to provide faster recovery, better vision, reduced need for postoperative eyedrops, and lower risk of complications. DMEK is currently recognized as the superior surgical technique for most patients. However, in the United States, DSAEK is still more commonly performed by doctors, because DMEK is a much more technically difficult operation, for the surgeon. This is why it is critical for patients with Fuchs dystrophy to receive care at cornea specialty centers with a long history of success with DMEK, before proceeding with care.