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In today’s video, I dive into the surprising science behind why lipedema fat—and stubborn fat in general—refuses to budge, no matter how much you diet or exercise. I’ll break down the latest research on the “epigenetic memory” of fat cells, a new discovery showing that fat cells can actually remember their obese state and hold onto those molecular changes, making long-term weight loss even more challenging. I discuss how hormones like leptin play a role in metabolism and appetite, why leptin resistance happens, and what that means for anyone struggling with lipedema or chronic stubborn fat. Most importantly, I explain how all of this science relates to lipedema: why affected fat cells are uniquely resistant, inflamed, and painful, and why traditional weight loss often fails. I share how liposuction for lipedema targets and removes these problematic fat cells, often providing real relief with less pain, improved mobility, and better quality of life. Hello, I’m Dr. Markelov, expert lipedema surgeon, Lipedema specialist, and double board certified plastic surgeon specializing in lipedema. 🔗 SOCIALS + WEBSITE Website - https://www.markelovmd.com/ Instagram - / markelovmd Facebook - / markelovmd 0:00 Introduction 0:12 New Research on Fat Cells 0:36 Epigenetic Memory of Fat 1:07 Why Weight Loss is Hard 1:37 Lipedema Fat Cells: What’s Different? 2:15 The Role of Leptin 2:31 Leptin, Weight Loss, and Leptin Resistance 3:16 Why Liposuction Works for Lipedema