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The first event on tobacco harm reduction (THR) in Brazil and Latin America. The discussions focus on key science topics such as the potential lives saved with THR and case studies from Sweden, Japan, the UK, New Zealand, and Germany. We also explore nicotine policy principles such as risk-proportionate regulation, youth prevention, labelling, cessation, and taxation, as well as consumer insights on the topics of misinformation, cessation motives and methods, flavours, and nicotine misperceptions. Experienced speakers from various fields, including public health, academia, and government, share their insights and knowledge on important topics. This event also marks the launch of the PAHRA website (https://pahra.net/), dedicated to providing accurate information on THR and related topics. Speakers: Dr Delon Human Prof Konstantinos Farsalinos Dr Christopher Russel Prof Mihaela Răescu Prof Adriana Gioda Dr Kgosi Letlape Dr Derek Yach Clive Bates Dr Diego Verrastro Dr Anders Milton Prof Heino Stöver Dr Marewa Glover Dr José Alejandro Chávez Fernández Patricia Kovacevic Federico N. Fernández Miguel Okumura Juan Facundo Teme Francisco Ordonez Érika Suzigan Cíntia Leci Rodrigues