Hemostasis | Primary Hemostasis | Physiology of Platelets, Clotting Factors and Fibrin скачать в хорошем качестве

Hemostasis | Primary Hemostasis | Physiology of Platelets, Clotting Factors and Fibrin

Bringing you all the knowledge about Hemostasis in a brand-new way! Gone are the days when you had to consult 3-4 medical books. sqadia.com has you covered! We have condensed the medical physiology of Hemostasis in a single medical video lecture, to make your medical study life easier. Sparing no detail and making it super easy to understand! In the end, you will have all the answers to the questions like: 🟡 What is hemostasis? 🟡 Why do we need hemostasis? 🟡 What are the hemostasis steps involved? 🟡 Which factors are involved? ▬ 🕘 Timestamps ▬▬▬▬▬▬▬▬▬▬ 00:00 - Local Vasodilators 00:35 - Vessel Damage 01:04 - Vasocontraction Causes 01:41 - Local Autacoid Factors 02:45 - Primary Hemostasis Physiology 03:06 - Platelet Clot Formation 03:43 - Adhesion of Platelets 04:14 - Von Willebrand Factor 04:58 - Activation of Platelets 07:02 - Thromboxane A2 09:30 - Aggregation of Platelets 10:34 - Bleeding Time 11:41 - Link to Primary Hemostasis Physiology Lecture on sqadia.com ▬ 📃 What is Hemostasis? ▬▬▬▬▬▬▬▬▬▬ To understand the word “hemostasis” meaning. We must break it down: 'Hemo' comes from an Ancient Greek word meaning, "blood". And 'Stasis', meaning "motionlessness or stopping". So together it will mean to stop the leakage of blood or prevention of blood loss from a damaged blood vessel. ▬ 📜 Hemostasis Steps ▬▬▬▬▬▬▬▬▬▬ 🟠 So our story will start with blood vessel damage or the pipe getting a leakage. First up, there will be immediate action which is termed vasoconstriction, to reduce the blood flow. 🟠 Then we have the temporary solution to the leak. You would gag the pipe leak temporarily with a cloth. In the body, this is known as the platelet clot or the platelet plug. This will be called primary hemostasis. 🟠 After that, we would call professional help, like a plumber to permanently fix the leak. This is known as the blood clot or secondary hemostasis; this stabilizes the platelet plug. 🟠 Lastly, after this repair process, fibrinolysis will take place, to redissolve the clot. ▬ 📃 Primary Hemostasis ▬▬▬▬▬▬▬▬▬▬ Primary hemostasis encompasses the platelet plug formation. The time required for this plug to form is merely 2-4 minutes, which is known as the “bleeding time”. Platelet clot formation covers 3 steps. Let's go into the details of all the factors involved in each step. 🔵 Adhesion of platelets to the damaged endothelial wall 🔵 Activation of platelets 🔵 Aggregation of platelets ▬ 📜 Secondary Hemostasis ▬▬▬▬▬▬▬▬▬▬ Secondary hemostasis involves the coagulation cascade and the eventual growth of fibrin meshwork into the blood clot to close the hole in the vessel permanently. Thus the platelet plug is stabilized. The main players in the coagulation cascade are the 12 clotting factors or coagulation factors. Watch the lecture to learn a fun mnemonic to memorize their names. The clotting factors are activated sequentially to yield thrombin. Thrombin then catalyzes the conversion of fibrinogen to fibrin meshwork. This meshwork is stabilized via factor VIII or fibrin-stabilizing factor. Explained through cool animations, three main steps are involved in the coagulation cascade: 🟢 Initiation 🟢 Amplification 🟢 Propagation All the details will be revealed in the video lecture. ▬ 📃 Fibrinolysis ▬▬▬▬▬▬▬▬▬▬ The process of redissolving the fibrin meshwork in the blood clot is called fibrinolysis. To prevent excessive clotting and occlusion of major blood vessels (thrombosis). Plasmin is a serine protease that is the main player in fibrinolysis. It proteolyzes the fibrin into fibrinopeptides. Watch the lecture to learn via animations to understand this process easily. Along with the detailed knowledge of the activators and inhibitors of fibrinolysis. What are you waiting for? Watch the lecture to learn the whole story of Hemostasis, engagingly and easily! ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻‍⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More #hemostasis #coagulation #physiology #pharmacologyclass #pharmacologylectures #blood #physiologylectures #physiology #blood #bloodcirculation #bloodgroup #hematology #medicallectures #medicalstudent