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In this episode of Cracking Addiction, we take an in-depth look at Delta-9-Tetrahydrocannabinol (THC) — the primary psychoactive compound in the cannabis plant. We explore how THC interacts with the body’s endocannabinoid system (ECS), focusing on its binding to CB1 and CB2 receptors. This interaction triggers a cascade of biochemical responses, including the release of neurotransmitters such as dopamine and serotonin. This leads to changes in perception, mood, memory, and motor function and often a sense of euphoria. The episode also breaks down the clinical effects of THC, including its well-known pain-relieving, anti-spasmodic, and appetite-stimulating properties. We examine how THC is used to treat conditions like chronic pain, multiple sclerosis (MS), and chemotherapy-induced nausea and vomiting. However, we also discuss the potential risks and side effects of THC use, such as anxiety, paranoia, cognitive impairment, and its association with psychosis in vulnerable individuals. Additionally, we touch on the various forms of THC products — from smoked or vaporized cannabis to edibles, oils, and topical applications — and their role in modern clinical practice. THC and Medical Cannabis Explained: Uses, Side Effects & How It Works on CB1 & CB2 Receptors This episode presents a balanced, evidence-based perspective on both the therapeutic potential and the cautionary concerns surrounding THC, making it an essential watch for anyone interested in the medical or psychological aspects of cannabis use.