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TOPIC- cAMP PATHWAY || IP3-DAG PATHWAY| GPCR (PART-2) For CSIR NET (CELL SIGNALING) Cyclic AMP is an important second messenger. It forms, as shown, when the membrane enzyme adenylyl cyclase is activated (as indicated, by the alpha subunit of a G protein). The cyclic AMP then goes on the activate specific proteins. The activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP), directly increasing the cAMP level. Four cAMP molecules are able to bind to the two R-subunits. Inositol triphosphate (IP3) and diacylglycerol (DAG) are important second messengers. Their formation begins with the binding of an extracellular regulatory molecule to a membrane receptor that activates a trimeric G protein.The IP3 diffuses to the endoplasmic reticulum, which stores Ca++.Protein kinase C, commonly abbreviated to PKC is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family **************************************************** ABOUT CHANNEL: This channel will have the syllabus wise lectures Video for CSIR-NET-Lifescience/GATE-Lifescience/BARC/ICMR-JRF/ICAR. ***************************************************** MORE VIDEOS ON CSIR NET (CELL SIGNALING) GPCR-PART 1: • G-PROTEIN COUPLED RECEPTOR (PART-1) | GPCR... GPCR-PART 2 (IP3 DAG PATHWAY and cAMP PATHWAY • cAMP PATHWAY || IP3-DAG PATHWAY| GPCR (PAR... CELL SIGNALING INTRODUCTION || CSIR NET || GATE | • CELL SIGNALING INTRODUCTION || CSIR NET ||... TYPE OF CELL SIGNALING | CSIR NET | GATE | CELL SIGNALING • TYPE OF CELL SIGNALING | CSIR NET | GATE |... LIGAND AND RECEPTOR (PART-1)-CSIR NET/GATE • LIGAND AND RECEPTOR (PART-1) || CELL SIGNA... LIGAND AND RECEPTOR (PART-2) |INTRACELLULAR RECEPTOR |-CSIR NET/GATE • INTRACELLULAR RECEPTORS || LIGAND AND REC... cell surface receptor | ligand and receptor (part-3) • CELL SURFACE RECEPTORS || CELL SIGNALING |... APOPTOSIS (PART-1)- CSIR NET • APOPTOSIS (Part-1)| Programmed Cell Death ... APOPTOSIS (PART-2) | what are caspases??- CSIR NET • APOPTOSIS (Part-2)| What are Caspases?? | ... APOPTOSIS (PART-3)| INTRINSIC PATHWAY-CSIR NET • INTRINSIC PATHWAY OF APOPTOSIS (Part-3) | ... APOPTOSIS (PART-4)| EXTRINSIC PATHWAY-CSIR NET • EXTRINSIC PATHWAY OF APOPTOSIS (Part-4) | ... APOPTOSIS IMPORTANT POINTS FOR CSIR NET • APOPTOSIS IN NEMATODES | BCl-2 gene analou... APOPTOSIS CSIR NET QUESTIONS • CSIR-NET SOLVED QUESTIONS ON APOPTOSIS || ... LIKE SHARE SUBSCRIBE FOR MORE SUCH VIDEOS