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Dr. Ebraheim’s educational animated video describes the difference between Benedictine Sign and O.K. Sign - Anterior Interosseous Nerve Injury. A patient with a high median nerve injury or anterior interosseous nerve injury can have two signs: 1- The Benedictine sign: patient with complete anterior interosseous nerve injury or a high medial nerve injury is asked to make a fist, the first and the second digits will have difficulty in flexing, while the other digits will flex. The third digit will be weak, while the fourth and fifth digits are normal. The position of the hand is similar to the position taken during a hand blessing. The Benedictine sign is different from ulnar claw hand. Ulnar claw hand refers to damage to the ulnar nerve and is seen when attempting to extend all the digits (leaving the 4th and 5th digits flexed). 2- Inability to do the O.K. sign: ask the patient to touch the tip of the thumb and the index finger together. If the distal pharynx cannot flex because of weakness of the anterior interosseous nerve then the patient cannot do the O.K. sign, that is because of weakness of the flexor pollicis longus and flexor digitorum profundus muscles. This complication can occur from a distal humeral fracture in children. The anterior interosseous nerve arises from the median nerve about 4-6 cm distal to the elbow, which is about 1.3 of the way down the forearm. The enterior interosseous nerve exits from the anterolateral aspect of the median nerve and it runs between the radius and the ulna on the interosseous membrane between and below the muscle of the flexor digitorum profundus and the flexor pollicis longus. The interosseous nerve supplies the muscles which lies in the deep compartment of the forearm, it is the: flexor digitorum profundus, flexor pollicis longus, pronator quadratus. The flexor digitorum longus to the index and the long finger is supplied by the anterior interosseous nerve. The medial part of the profundus is supplied by the ulnar nerve (FDP has dual innervation). The anterior interosseous nerve passes dorsal to the pronator quadratus muscle with the anterior interosseous artery and provides innervation to the volar wrist capsule. The terminal branches of the anterior interosseous nerve innervates the carpal joint capsule. Patient with Martin-Gruber: connection between the median nerve, or anterior interosseous nerve and the ulnar nerve in the forearm may present with intrinsic muscle weakness. It may be differentiated also from Parsonage-Turner syndrome (acute brachial plexus neuritis) and patient may have pain in the affected extremity. In anterior interosseous nerve entrapment, the median nerve conduction study result will be normal; however the needle EMG of the anterior interosseous innervated muscle will be abnormal, it is a motor nerve and not a sensory nerve. Become a friend on facebook: / drebraheim Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC Donate to the University of Toledo Foundation Department of Orthopaedic Surgery Endowed Chair Fund: https://www.utfoundation.org/foundati...