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In this IFSO Santiago 2025 interview, Dr. Francesco Rubino, consultant bariatric surgeon from King’s College London, explains clinical obesity—a newly defined disease that goes beyond BMI and identifies when excess adiposity causes organ dysfunction. Dr. Rubino distinguishes between preclinical obesity (risk of future disease) and clinical obesity (disease present now), emphasizing the importance of personalized interventions. He explains that treatment options include: Bariatric (metabolic) surgery: Long-term effective weight loss, diabetes remission, and improved organ function. Medications (GLP-1 agonists like semaglutide): Useful for prevention, metabolic improvement, or as adjuncts to surgery. Lifestyle interventions: Still important, but alone may be insufficient for severe obesity. He highlights that obesity is multifactorial, influenced by biological, environmental, and social factors, and that early intervention improves outcomes and quality of life. Chile is recognized as a leader in surgical treatment of obesity, and the conference emphasizes combining therapies for precision, personalized care. Visit https://www.ifso.com/ for more information.