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The BMJ's Helen MacDonald speaks with Gordon Guyatt, a distinguished professor of medicine and health research methods at McMaster University in Canada. 📖 Read about Core GRADE on The BMJ's website: https://www.bmj.com/content/bmj/389/b... Gordon introduces us to the Core GRADE system, which is a simplified, essential version of the GRADE approach used globally to rate the certainty of evidence from systematic reviews and develop health recommendations and guidelines. We delve into the history and evolution of the GRADE system, its widespread influence, and the need for a 'living' Core GRADE document to keep up with advancements in science. Gordon also discusses the controversies and challenges within evidence-based medicine, the importance of values and preferences in clinical decision-making, and future directions for incorporating patient outcomes and artificial intelligence to enhance medical guidelines. 00:00 Coming up 00:41 What is Core GRADE? 02:01 Challenges and Innovations in GRADE 04:42 Controversies in Evidence-Based Medicine 11:18 The Role of Values and Preferences 19:34 Patient Involvement and Shared Decision Making 25:38 Future Directions and Challenges 31:14 Conclusion and Final Thoughts The BMJ Medicine & Science podcast is released fortnightly. ------------------------------------------------------------------------------------------------------------------------ 🎙️ Listen To The Podcast: https://podcasts.apple.com/gb/podcast... https://open.spotify.com/show/2FKxpbv...