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hereditary hemorrhagic telangiectasia

(HHT, Osler-Weber-Rendu disease, OWRD) An autosomal dominant disorder that causes arteriovenous malformations, abnormal tangle of blood vessels connecting arteries and veins, which disrupts normal blood flow and oxygen circulation. The most common locations affected are the nose, lungs, brain, and liver. Spontaneous and unprovoked epistaxis (nosebleeds), sometimes on a daily basis, are the most common feature. Persistent bleeding from the nose and the intestinal tract can result in severe iron deficiency anemia. The arteriovenous malformations may enlarge over time and can bleed or rupture, sometimes causing catastrophic complications.