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Nitrous oxide (Inhalational anesthetics)

Nitrous oxide, or laughing gas, has played a crucial role in anesthesia for over 150 years. In this video, we dive into its history, mechanism of action, and unique physiological effects, including the concentration effect and second gas effect. We’ll also explore its clinical uses, side effects, and findings from the ENIGMA trials, which questioned its routine use in major surgeries. 🔹 Topics Covered: ✅ History of nitrous oxide in medicine ✅ How nitrous oxide works – Mechanism of action ✅ The concentration effect and second gas effect ✅ Clinical applications in anesthesia and sedation ✅ Adverse effects, including nausea, B12 deficiency, and cardiovascular concerns ✅ Insights from the ENIGMA trials – Should nitrous oxide still be used? Link to mechanism of action:    • Inhalation anesthetics | Mechanism of action   Link to MAC:    • MAC of inhalational agents (Minimum Alveol...   Link pharmacokinetic of inhalation agent:    • Inhalational Anesthetics Pharmacokinetic |...   Link to medical gas system:    • Cylinder (Part 2)| medical|Pin index safet...