NSS 2023.12.15 - Brian Pogue “Medical Physics Research in Cherenkov Imaging & FLASH Mechanisms” скачать в хорошем качестве

NSS 2023.12.15 - Brian Pogue “Medical Physics Research in Cherenkov Imaging & FLASH Mechanisms”

MPU Noon Seminar Series Speaker: Brian Pogue, PhD Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin Title: "Medical Physics Research in Cherenkov Imaging & FLASH Mechanisms" Abstract: This talk will review the research developments in medical physics that are stimulated by the potential to improve radiotherapy. The first illustration comes from optical imaging of the Cherenkov emission from patients, which was developed into a real time imaging system and translated to a product. This Cherenkov imaging provides a direct view into the treatment vault, showing the therapy team the radiotherapy beam delivery on the patient skin. Studies that examine incidents observed of off-target dose are examined and the developing evidence for the need for Cherenkov imaging in clinical radiotherapy is shown from prospective and retrospective trials. The second illustration is in the field of FLASH radiotherapy, where ultrahigh dose rate radiation beams are utilized to achieve a moderate reduction in normal tissue damage. This high dose rate has a reduced oxygen consumption in vivo, and studies of this reduction show correlation to potential reduced oxygen-mediated damage. Recent results examining this oxygen-FLASH effect are examined from mouse skin assay, radiochemistry assays and basic dosimetry work. Biographical Summary: Brian Pogue is Chair of the Department of Medical Physics, University of Wisconsin-Madison, and Fellow of Optica, SPIE, AIMBE, AAPM and National Academy of Inventors. After receiving his PhD at McMaster in Canada, he joined Harvard Medical School as a post doc. He was then an engineering faculty member at Dartmouth for 25 years, founding their Medical Physics Education Program, and transitioned to Wisconsin in 2022. His research focus is at the intersection of optical devices in medical physics and biomedical engineering, developing Cherenkov imaging for visualization of radiation dose in radiotherapy, and in molecular sensing in surgical oncology. He has founded 3 active companies, including DoseOptics LLC, manufacturing Cherenkov imaging systems. He has published 500 peer-reviewed publications, filed 14 patents with 29 pending, and received over $50 million in NIH support. Dr Pogue is Editor-in-Chief of the Journal of Biomedical Optics published by SPIE.