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AI in healthcare can save lives-or put them at risk. This episode explores guardrails, safety LLMs, regulation, and why generic AI controls fail in clinical settings. Timestamps: 00:00 Introduction 01:26 What are LLM guardrails and why do they matter in healthcare 02:36 Why AI hallucinations are dangerous in medical settings 03:47 Why people still use chatbots for medical advice 05:13 Why generic AI safety tools fail in healthcare 06:16 Regulation pressure: US vs Europe 09:03 Guardrail frameworks: Guardrails AI, NeMo, Llama Guard 15:08 Safety LLMs and red teaming medical AI 22:17 Why healthcare AI needs application-specific testing 27:49 Shift-left AI safety and responsible design 32:44 The ELIZA effect 37:27 Practical advice for teams building healthcare AI 𝗥𝗲𝘀𝗼𝘂𝗿𝗰𝗲𝘀 𝗳𝗼𝗿 𝗟𝗶𝘀𝘁𝗲𝗻𝗲𝗿𝘀 ► Papers: Hakim et al. (2025) "The need for guardrails with large language models in pharmacovigilance." Meta's Llama Guard paper: "Llama Guard: LLM-based Input-Output Safeguard for Human-AI Conversations" (arXiv:2312.06674) Ayala-Lauroba et al. (2024) "Enhancing Guardrails for Safe and Secure Healthcare AI" (arXiv:2409.17190) Code and Models: Hakim et al. analysis code: https://github.com/jlpainter/llm-guar... Llama Guard: Available on Hugging Face (requires approval) gpt-oss-safeguard: https://huggingface.co/openai/gpt-oss... (Apache 2.0) Medical Ontologies: MedDRA (Medical Dictionary for Regulatory Activities): https://www.meddra.org/ WHO Drug Dictionary: Via Uppsala Monitoring Centre Regulatory Guidance: EMA AI Reflection Paper: https://www.ema.europa.eu/en/about-us... FDA AI Guidance: Available on FDA.gov LISTEN ON ► Apple Podcasts: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/2XNrQBe... Amazon Music: https://music.amazon.com/podcasts/5b1... FOLLOW ► Website: https://www.johnsnowlabs.com/ LinkedIn: / johnsnowlabs Facebook: / johnsnowlabsinc X (Twitter): https://x.com/JohnSnowLabs #HealthcareAI #AIGuardrails #MedicalAI #AISafety #AIEthics #HealthTech #AIRegulation #DigitalHealth #AIinMedicine #MLOps #AICompliance #AIHallucinations