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In this video, we delve into the groundbreaking TORCH-E trial, which has the potential to transform the way we approach early low-lying rectal cancer. The trial's innovative use of immunotherapy-based total neoadjuvant therapy (iTNT) offers a ray of hope for patients, providing an opportunity to avoid radical surgery and its associated risks. We explore the study design, patient population, and remarkable results achieved. With a complete response rate of 72.7% and an organ preservation rate of 60.6%, the trial demonstrates the power of combining short-course radiotherapy, chemotherapy, and immunotherapy. Learn about the potential of immune-based priming to amplify tumor regression and the implications for rectal cancer management. The findings suggest a path toward organ-sparing strategies and improved postoperative quality of life. Join us as we discuss the clinical implications and the future of rectal cancer treatment, as we move towards a more patient-centric and effective approach.