What is VIPoma? скачать в хорошем качестве

What is VIPoma?

VIPoma is a rare type of neuroendocrine tumor that typically arises from the pancreas and secretes excessive amounts of vasoactive intestinal peptide (VIP). ⸻ 🔍 Key Facts About VIPoma: 1. What is VIP? VIP (vasoactive intestinal peptide) is a hormone that helps regulate water secretion in the intestines, smooth muscle activity, and blood flow. ⸻ ⚠️ Classic Symptoms – “WDHA Syndrome”: VIPomas cause a characteristic triad known as WDHA Syndrome: • Watery • Diarrhea • Hypokalemia (low potassium) • Achlorhydria (low stomach acid) Patients often have profuse, chronic watery diarrhea — up to several liters per day — leading to dehydration and electrolyte imbalances. ⸻ 🧪 Diagnosis: • Serum VIP levels: Elevated (75 pg/mL is suggestive) • Imaging: CT/MRI to localize the tumor • Octreotide scan or PET for metastasis ⸻ 💊 Treatment: 1. Supportive care: • IV fluids & electrolyte correction • Antidiarrheals (e.g., octreotide) 2. Definitive treatment: • Surgical resection if localized • Somatostatin analogs (e.g., octreotide) for symptom control • Chemotherapy if metastatic ⸻ 📉 Prognosis: • VIPomas are rare and often malignant. • Early detection and treatment can improve outcomes.