Ocular Surface Squamous Neoplasia Lecture - Carol Karp, MD скачать в хорошем качестве

Ocular Surface Squamous Neoplasia Lecture - Carol Karp, MD

Ocular Surface Squamous Neoplasia Lecture - Carol Karp, MD Bascom Palmer Eye Institute & Oftalmo Universiy Ocular Surface Squamous Neoplasia (OSSN), its diagnosis, risk factors, and treatment options. The lecture was aimed at expanding the audience's knowledge on cornea-related topics, with a special focus on OSSN, leveraging the virtual platform to reach a broader audience during the COVID-19 pandemic. Risk Factors and Diagnosis: UVB Exposure: The primary risk factor for OSSN, emphasizing the importance of protecting the eyes from sun exposure. Genetic Conditions: Conditions like xeroderma pigmentosum, which impairs the body's ability to repair DNA damage, leading to increased cancer risk. Viral Infections: HPV's role as a cofactor in OSSN, similar to its involvement in other mucosal cancers. Immunodeficiency: The lecture highlighted an interesting observation where younger patients with OSSN were often found to be HIV positive, underscoring the link between immunosuppression and increased cancer risk. Clinical Presentation and Methods: OSSN can present in various forms, from mild dysplasia to invasive squamous cell carcinoma. Diagnosis involves a combination of clinical acumen and biopsy, with impression cytology and high-resolution OCT (Optical Coherence Tomography) being valuable diagnostic tools. Treatment Options: The lecture detailed the different treatment modalities, including surgical excision and topical chemotherapy. Topical Chemotherapy: Dr. Karp expressed a preference for topical treatments like 5-fluorouracil (5-FU) and interferon, highlighting their advantages in treating the entire ocular surface comprehensively. The discussion included detailed protocols for administering these drugs and managing potential side effects. Surgical Intervention: While effective, surgery can lead to complications such as stem cell deficiency and scarring. Dr. Karp advocated for considering medical therapy, especially in cases of extensive or recurrent OSSN, to preserve the ocular surface. Insights Based on Numbers: The significant number of OSSN cases linked to UV exposure underscores the need for increased public awareness about the importance of eye protection from sunlight. The 50% rate of HIV positivity in OSSN patients under 50 years old in Dr. Karp's early observations points to the critical need for comprehensive patient evaluation, including immune status. Example Exploratory Questions: How does UVB exposure contribute to the development of OSSN, and what preventive measures can be taken? (Enter 1 to ask) In what ways do immunodeficiency and viral infections like HPV exacerbate the risk of OSSN, and how is this managed in clinical practice? (Enter 2 to ask) What are the comparative advantages and disadvantages of topical chemotherapy versus surgical intervention in the treatment of OSSN? (Enter 3 to ask) This lecture offers valuable insights into OSSN, highlighting the importance of understanding its multifactorial risk factors, the effectiveness of various diagnostic tools, and the strategic approach to treatment. For more details, consider watching the lecture on YouTube.