MicroRNA-21 inhibition reduces profibrotic factor release from platelets скачать в хорошем качестве

MicroRNA-21 inhibition reduces profibrotic factor release from platelets

Fibrosis is characterized by excess ECM deposition and occurs in a variety of organ systems, resulting in reduced function and possible failure. Therapeutic strategies for limiting and preventing fibrosis are lacking, and drivers of this pathogenic response are not fully understood. In this episode, Manuel Mayr and colleagues used a proteomic approach to evaluate the effect of targeting microRNA-21 (miR-21), which has been implicated in the fibrogenic response. While inhibition of miR-21 did not markedly alter ECM deposition, reduction of miR-21 limited the release of TGF-beta1 and other profibrotic factors from platelets. These results provide a previously unrecognized mechanism for the known antifibrotic effects of miR-21 inhibition.