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The Vascular Tissue Challenge, a NASA Centennial Challenges competition, offers a $500,000 prize to be divided among the first three teams that successfully create thick, metabolically-functional human vascularized organ tissue in a controlled laboratory environment. Competitors must produce vascularized tissue that is more than .39 inches (1 centimeter) in thickness and maintains more than 85 percent survival of the required cells throughout a 30-day trial period. Teams must demonstrate three successful trials with at least a 75 percent success rate to win an award. In addition to the laboratory trials, teams also must submit a proposal that details how they would further advance some aspect of their research through a microgravity experiment that could be conducted in the U.S. National Laboratory on the International Space Station. Studying these effects will help create ways to mitigate negative effects of space travel on humans during long duration, deep space missions. On Earth, the vascularized tissue could be used in pharmaceutical testing or disease modeling. The challenge also could accelerate new research and development in the field of organ transplants. For more information about the Vascular Tissue Challenge, visit www.nasa.gov/vtchallenge.