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This Double Take video from the New England Journal of Medicine describes the case of a man with persistent diffuse abdominal pain, fatigue, and anorexia with subsequent weight loss. Based on a Clinical Problem-Solving article published in the Journal, the video explores the broad differential diagnosis of abdominal pain and how a clinician could assess a patient with a constellation of nonspecific symptoms to identify a unifying diagnosis. For further reading, the Clinical Problem-Solving article referenced in this video is available at https://www.nejm.org/doi/full/10.1056... Led Astray (Young et al., in the August 5, 2020, issue of the Journal). #medicaleducation #clinicalmedicine #nejm #doubletake #clinicalproblemsolving #diagnosticevaluation #differentialdiagnosis The New England Journal of Medicine is the world’s leading general medical journal. Continuously published for over 200 years, the Journal publishes peer-reviewed research along with interactive clinical content for physicians, educators, and the global medical community at NEJM.org.