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Causes Risk Factors Anyone can develop CKD - at any age. However, some people are at a higher risk than others. The most common CKD risk factors are: Diabetes High blood pressure (hypertension) Heart disease and/or heart failure Obesity Over the age of 60 Family history of CKD or kidney failure Personal history of acute kidney injury (AKI) Smoking and/or use of tobacco products For many people, CKD is not caused by just one reason. Instead, it is a result of many physical, environmental, and social factors. Early detection is important – CKD often begins without causing any noticeable symptoms. Knowing the risk factors can help you know your level of risk and if you should get checked for CKD. Other causes CKD can also be caused by many other conditions or circumstances. Some examples include: Glomerular diseases: glomerulonephritis, IgA nephropathy (IgAN), and HIV nephropathy Inherited conditions: polycystic kidney disease Autoimmune conditions: lupus (lupus nephritis) Severe infections