Reimagining Druggability using Chemoproteomic Platforms скачать в хорошем качестве

Reimagining Druggability using Chemoproteomic Platforms

One of the major challenges in modern drug discovery is that more than 90% of the human proteome is currently considered “undruggable”, as most proteins do not possess known binding pockets or “ligandable hotspots” that can be pharmacologically and functionally targeted for therapeutic purposes. Tackling the undruggable proteome requires the development of innovative technologies for ligand discovery and novel therapeutic modalities to functionally manipulate these proteins for therapeutic benefit. In this Flash Talk, Daniel Nomura, Professor of Chemical Biology and Molecular Therapeutics, will present his group’s recent advances in applying chemoproteomic platforms to identify and pharmacologically target unique and novel ligandable hotspots for disease therapy. He will also highlight how chemoproteomics-enabled covalent ligand discovery approaches are expanding the landscape of targeted protein degradation and other induced-proximity therapeutic modalities. 00:00 Welcome and Introduction 10:57 Drug Hunter Platform - Structure Search 14:00 Presentation 48:48 Q&A If your company doesn’t have a subscription yet, reach out here to inquire about access: https://drughunter.com/plans Recorded on October 30th 2025, as a Drug Hunter Flash Talk. Sign up to be notified of future sessions here: https://drughunter.com/flash-talk-ser... Sign up for our free newsletter here: https://drughunter.com/newsletter-sig...