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José Ignacio Barraquer: A Pioneer in Ophthalmology José Ignacio Barraquer’s work in refractive surgery, particularly his invention of the microkeratome and keratomileusis techniques, revolutionized vision correction. His contributions laid the foundation for modern procedures like LASIK and SMILE, and his legacy continues to inspire innovation in the field of ophthalmology. The Epithelium and Its Role in Refractive Surgery The corneal epithelium plays a crucial role in refractive surgery, compensating for stromal irregularities. My interest in the epithelium began during my medical school research with high-frequency ultrasound, which led to the development of epithelial mapping. This technique allows us to visualize how the epithelium thickens over depressions and thins over peaks, providing critical insights into diagnosing keratoconus and managing post-refractive surgery outcomes. High-Frequency Ultrasound for Corneal Imaging High-frequency ultrasound (VHFU) brought a new level of precision to corneal imaging, allowing us to measure epithelial thickness with micron-level accuracy. This has been instrumental in detecting early-stage keratoconus and improving post-surgical evaluations. Epithelial mapping has become a key tool in diagnosing corneal conditions, especially in cases where topography alone is inconclusive. Epithelial Mapping for Keratoconus Diagnosis Epithelial mapping helps distinguish normal eyes from those with keratoconus by revealing compensatory changes in epithelial thickness. This tool has significantly improved our ability to diagnose keratoconus in borderline cases, reducing the risk of ectasia in refractive surgery patients. ICL Sizing and Sulcus-to-Sulcus Measurements ICL sizing has evolved from relying on white-to-white measurements to incorporating sulcus-to-sulcus measurements and anatomical factors like lens rise. My son Max Reinstein has further advanced this area by integrating AI and predictive modeling to improve vault predictions. These advancements ensure more accurate ICL sizing, reducing complications and improving patient outcomes. Multifocality, Monovision, and Spherical Aberration for Presbyopia Correction Traditional presbyopia correction methods, such as multifocality and monovision, often lead to compromises in visual quality. The PRESBYOND procedure, which I developed, uses LASIK to induce spherical aberration, increasing depth of field and offering a more natural range of vision. This approach avoids the drawbacks of multifocal lenses and monovision, providing better near and distance vision without visual disturbances. Presbyopia Correction on the Cornea vs. Lens Corneal-based presbyopia correction, like PRESBYOND, offers advantages over lens-based solutions such as multifocal IOLs. By manipulating spherical aberration to enhance depth of field, we can achieve excellent vision at all distances without the side effects associated with multifocal lenses. Corneal treatments are also reversible and adjustable, providing flexibility as presbyopia progresses. Legacy and Future Directions in Refractive Surgery Inspired by Barraquer’s pioneering work, my focus is on advancing refractive surgery through innovations in imaging, AI, and surgical precision. The future of the field lies in integrating these technologies to improve patient outcomes while maintaining the highest standards of safety and care.