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Lupus and Mixed Connective Tissue Disorder (MCTD) can look similar, but they’re not the same. This video breaks down the overlap and key distinctions between these systemic autoimmune diseases, including symptoms like Raynaud’s phenomenon, muscle inflammation, and skin tightening. Learn why the RNP antibody is a critical marker for MCTD and how diagnoses can evolve over time. Don’t assume new symptoms are “just lupus”—they might indicate something more. 🔗 Links: Your Appointment Home Run Handbook - https://bit.ly/4heAouK The guide you need to tell your doc your story -and get answers once and for all! 🎥 watch more: 3 Questions answered about Raynauds - • 3 Questions Answered about Raynaud's Syndrome Top 10 things to know about Lupus - Part 1 - • Top 10 things you need to know about Lupus Top 10 things to know about Lupus Part 2 - • Top 10 (continued!) Lupus facts you need t... 💡Video Key Takeaways ✔️ Both conditions are systemic autoimmune diseases with overlapping symptoms like fatigue, brain fog, rashes, and joint pain. However, MCTD combines features of lupus, scleroderma, and myositis. ✔️ Key indicators include Raynaud’s phenomenon, muscle inflammation (evident through symptoms and elevated CK, AST, or ALT levels), skin tightening due to fibrosis, and the presence of the RNP antibody. ✔️ The RNP antibody is highly specific for MCTD and often prompts deeper investigation into the diagnosis. ✔️ While many treatments overlap for lupus and MCTD, the latter’s higher risk for fibrosis in the lungs, esophagus, or skin necessitates a distinct management strategy. ✔️ Autoimmune diseases are dynamic; it’s not uncommon for a diagnosis to shift from lupus to MCTD over time, requiring constant reevaluation of symptoms and testing. ⏱️Time Stamps: 0:00 Intro 0:54 Why the SLE and MCTD distinction matters 2:32 Raynaud’s Phenomenon 4:06 Myositis 6:40 Skin Changes 7:25 The RNP antibody 7:58 Treatment for SLE and MCTD **Please note - we do not provide medical advice, opinions or diagnosis via email, phone or social media messaging. 👩🏻⚕️ About me: Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor. * The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.*