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Graft-versus-Host Disease: Eyes

Summary: The eyes are one of the most common sites for graft-versus-host-disease following stem cell transplantation. This presentation describes the most typical forms of ocular GVHD and the wide array of remedies to effectively treat symptoms of this problem. (Note: In this presentation, when the speaker uses the term bone marrow transplants, it includes stem cell and cord blood transplants as well.) Presenter: Jessica Ciralsky MD, Weill Cornell Ophthalmology To read the transcript, go to: https://www.bmtinfonet.org/video/graf... Highlights: About half of transplant patients will experience ocular graft-versus-host-disease (GVHD) after a transplant using donor cells and up to 90% may experience it if they have GVHD elsewhere in the body. Ocular graft-versus-host disease can lead to disabling pain and blindness if not treated. Early detection, diagnosis and treatment are important in preventing long-term complications. Dry eye is an inflammatory disorder than can be a severe, burdensome form of ocular GVHD. Treatments for ocular GVHD can decrease this inflammation and improve sight April 2023, Part of the Virtual Celebrating a Second Chance at Life Survivorship Symposium Presentation is 34 minutes long with 17 minutes of Q & A Key Points: (02:53): Ocular GVHD affects the ocular surface of the eye, tear glands, and oil glands. (06:56): Rapid evaporation can limit tear production or quality and produce dry eye. (15:15): Lubrication for ocular GVHD gets more tears to the surface through several types of artificial tear products. (15:44): Preservative-free tears are preferable for ocular GVHD and they come in different viscosities. (17:49): Nighttime ocular GVHD can be treated with ointments, moisture goggles, or punctal plugs. (21:10): Serum tears, made from a patient’s own blood, act more like natural tears in treating ocular GVHD. (22:10): Scleral lenses are made for dry eye patients and can be an effective treatment for ocular GVHD. (27:41): Surgical options are possible for ocular GVHD when all else fails. (29:38): In the most severe cases of ocular GVHD, corneal transplantation is an option. (31:36): Self-care remedies for ocular GVHD include artificial tears, warm compresses, and night goggles. Meet the speaker: https://weillcornell.org/jbciralsky WHO WE ARE: BMT InfoNet is dedicated to providing patients and their loved ones with emotional support and high quality, easy-to-understand information about blood stem cell transplants (bone marrow, peripheral blood and cord blood) and other cellular therapies. Whether you are just beginning your transplant or cellular therapy journey, or learning to manage the joys and challenges of survivorship, BMT InfoNet is here to help before, during and after treatment. Our goal is to empower you with credible information and emotional support, so that you can take a more active role in decisions affecting your health. http://www.bmtinfonet.org VISIT US ON SOCIAL MEDIA:   / bmtinfonet     / bonemarrowstemcelltransplantclub     / bmtinfonet     / bmtinfonet     / bmt-infonet