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For the diagnosis of type 1 neurofibromatosis, two or more of the following clinical features must be present: Six or more café-au-lait macules; in prepubertal children each macule must be more than 5 mm in greatest diameter, while in postpubertal 15 mm is the cut-off Two or more neurofibromas of any type or one plexiform neurofibroma Two or more Lisch nodules, which are Iris hamartomas. Freckling in the axillary or inguinal regions Optic glioma Distinctive bony lesion A first-degree relative with NF1 based upon the above criteria Music: https://www.bensound.com 📺 Subscribe To My Channel and Get More Great Quizzes and Tutorials / @med4vl #FOAMped #MedEd #pediatrics Disclaimer: All the information provided by Medical Education for Visual Learners and associated videos are strictly for informational purposes only. It is not intended as a substitute for medical advice from your health care provider or physician. It should not be used to overrule the advice of a qualified healthcare provider, nor to provide advice for emergency medical treatment. If you think that you or someone that you know may be suffering from a medical condition, then please consult your physician or seek immediate medical attention.