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Paraneoplastic syndromes are “hidden alarms”—immune or hormonal reactions to cancer that can appear months before a tumor is found. In this video we explain in simple terms what they are, why they matter for early detection, how they mimic other diseases, which skin/nerve/hormone/blood signs you must not ignore, how doctors diagnose (antibodies, hormones, PET/CT), and why treating the cancer first is key. Thanks to our YouTube & Patreon supporters for making evidence-based videos possible. Awareness saves lives. ----------------------------------------------------------------------------------------------------------- Timestamps (Chapters) 0:00 – Intro: the “hidden alarms” of cancer 0:41 – What paraneoplastic syndromes are (in simple terms) 1:38 – Two core mechanisms: immune cross-fire & ectopic hormones 2:55 – Why this matters: first sign months before cancer 3:40 – A clinical case: missed ovarian cancer → lessons 5:10 – Diagnosis confirmed late: what went wrong 5:58 – Nervous system syndromes: limbic encephalitis, cerebellar degeneration 6:49 – More neuro: opsoclonus-myoclonus, Lambert-Eaton, MG, retinopathy 7:42 – Endocrine & metabolic: Cushing’s, SIADH, hypercalcemia, hypoglycemia, carcinoid 8:40 – Skin & muscle clues: acanthosis, Leser–Trélat, pemphigus, dermatomyositis, Sweet’s 9:35 – Blood & clotting: Trousseau’s, thrombocytosis, NBTE, DIC 10:10 – Rheumatology & bone: arthritis, RS3PE, clubbing 10:42 – Kidneys & systemic: nephrotic syndrome, cachexia, fevers 11:00 – How doctors diagnose: antibodies, hormones, PET/CT, rule-outs 11:45 – Treatment: treat the cancer first; immunotherapy & symptom control 12:20 – Why viewers should care: signs you mustn’t ignore 12:45 – Recap & thanks to channel supporters