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#PICEnglish, #1stSmesterBPharm #MedicoPharmaLectures, #BPharm Hello Everyone, Greetings for the day...!!! Download Notes in PDF using Facebook Group: / files Instagram-https://www.instagram.com/medicopharm... Welcome back to MedicoPharma Lectures once again. This Lecture is about the Chloride Limit Test in Hindi. An English version of this video is also available. Introduction: Chloride is a harmless impurity commonly present in pharmaceutical solvents like water. Though it is harmless, its presence in large quantities may lead to the decreased therapeutic value of pharmaceutical preparations and also create technical problems during drug formulation. That's why a limit test for chloride is carried out. Principal: The principal behind the limit test for chloride is based upon reaction between soluble chloride impurity and Silver nitrate reagent in the presence of dilute nitric acid to produce silver chloride convalescence. Thus produced opalescence is compared with Standard opalescence which is produced by a specific amount of standard sodium chloride under the same reaction condition. Reactions involved in limit test for chloride, procedures, observation, and results are explained in videos. Why dilute nitric acid is added in the limit test for chloride? -Dilute nitric acid is used to prevent interference of other impurities (like carbonate, bicarbonate, phosphate, etc.) which are also present in the sample and can produce white precipitate resulting in the alteration in observation and results. -The precipitates thus produced by these impurities are soluble in dilute nitric acid but silver chloride opalescence is not soluble. -Moreover, dilute nitric acid enhances the formation of Silver chloride by the common ion effect. Please see the ionization reaction of the Silver nitrate and nitric acid in the video under note section. Pharmaceutical Inorganic Chemistry: Playlist: • Lecture_01_PIC_ Impurity, Types of Impurit... Limit Test • Lecture_02_PIC_Introduction to Limit Test_... Pharmacology Videos: • Lecture 01: Introduction to General Pharma... Facebook Page- / medicopharmalecture Thanks & regards, MedicoPharma Lectures