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Subscribe to our educational content and resources by visiting us at https://systole.live. In Episode 1 of The Coronary Corner by SYSTOLE: CT-guided PCI - Why? hosted by Drs. Yader Sandoval and Emmanouil S. Brilakis, the discussion focuses on the rationale for incorporating coronary computed tomography angiography (CCTA) into planning for percutaneous coronary intervention (PCI). They explain how CCTA provides detailed anatomical information, including plaque characteristics and calcium distribution, which can be helpful for procedural planning. This imaging modality supports lesion assessment and identification of optimal fluoroscopic angles, potentially reducing procedure time, contrast use, and complications. The conversation also explores practical considerations and challenges associated with CT-guided PCI. Drs. Sandoval and Brilakis emphasize the importance of collaboration among care teams, advances in imaging technologies, and the development of clear protocols to support clinical implementation. They note that while CT-guided PCI shows promise for improving procedural planning and outcomes, its adoption requires careful integration into workflows and continued evidence development. The discussion highlights how imaging tools are playing an increasing role in contemporary interventional practice.