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Manil Suri and Daniel Morgan are an unusual team: Manil is a mathematics professor and author, while Daniel is a physician and professor of epidemiology, public health, and infectious diseases. But they recently teamed up for a First Opinion essay, “Diagnostic tests for rare conditions present a mathematical conundrum,” in which they write about how the more rare a disease ease, the more likely a test will return a false positive. Host Torie Bosch spoke with Manil and Daniel about how false positives can cause major problems, how both physicians and patients misunderstand statistics, and how their work plays out in their own lives. More from STAT: Become a subscriber: https://www.statnews.com/stat-plus/ Watch Full Episodes: / @statnews Newsletters: https://www.statnews.com/signup/ STAT events: https://www.statnews.com/stat-events/ Facebook: / statnews Twitter: / statnews Instagram: / statnews Flipboard: rb.gy/3xnsxr STAT Reports: https://rb.gy/rexfwj STAT eBooks: https://rb.gy/eme3h5 ABOUT STAT: Founded in 2015, STAT is a global digital media brand that focuses on delivering fast, deep, and tough-minded journalism about the life sciences industries to over six million monthly site visitors and an additional 20 million readers on the Apple News app. STAT takes you inside academic labs, biotech boardrooms, and political backrooms, casting a critical eye on scientific discoveries, scrutinizing corporate strategies, and chronicling the roiling battles for talent, money, and market share. With an award-winning newsroom, STAT provides indispensable insights and exclusive stories on the technologies, personalities, power brokers, and political forces driving massive changes in the life sciences industry — and a revolution in human health.