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Across the country, many states have formed partnerships with robust nonprofit health data networks that have grown beyond the limited scope of traditional health information exchanges. These organizations now operate as Health Data Utilities (HDUs), playing a vital role in their state’s health data infrastructure. While their specific functions, maturity levels, and service offerings may differ, they share a set of foundational capabilities—delivering real-time health data and analytics to support both public and private sector needs. Beyond strengthening the connections between public health and clinical care coordination, HDUs are mobilizing to leverage artificial intelligence to enhance the efficiency and impact of public health surveillance—particularly syndromic surveillance, electronic lab reporting, and electronic case reporting—that can be coordinated and aggregated to meet national needs beyond their state. By collaborating with existing national networks, HDUs are well-positioned to quickly help modernize nationwide public health data infrastructure, increasing preparedness for future pandemics and national emergencies and responding to ongoing, chronic health issues. With their comprehensive and real-time data collected from sources which go beyond provider and health system to include claims and other health-related data, HDUs can also work in concert with national networks to serve as a key component of the US approach to national interoperability. Hear from Consortium for State and Regional Interoperability (CSRI), a collection of the nation’s largest and most robust nonprofit HDUs, who will share opportunities for HDUs to meet the state and federal health data infrastructure needs in partnership with national networks and TEFCA.