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G Protein Coupled Receptors (GPCR) & G Proteins

Find notes here: https://www.nonstopneuron.com/post/g-... Explore our entire animation video library at: https://www.nonstopneuron.com/ Video Summary: G protein-coupled receptors are transmembrane proteins with 7 transmembrane segments. They are also called 7 pass receptors or serpentine receptors. As per the name, they are coupled with G proteins. G proteins have GTPase activity and they bind with GTP or GDP. Heterotrimeric G proteins have α, β, and γ subunits with α subunit having GTPase activity. Different trimeric G proteins are Gs, Gi, Go and Gq. This group mediates the response to a wide range of signal molecules. Monomeric G protein is similar to the α subunit of heterotrimeric G protein. They include Ras, Rho, Rab, Arf, and Ran families of G proteins. They regulate gene expression and cell proliferation, differentiation, and survival. Now the cycle of subunits of heterotrimeric G proteins during signaling. Under resting state, the complex is associated with the receptor and the α subunit is bound to GDP. The binding of a ligand with the receptor causes the release of GDP and binding of GTP. This in turn causes of release of the free α subunit and βγ complex. They both affect different downstream signaling molecules. Eventually, the GTPase activity of the α subunit causes hydrolysis of GTP into GDP and phosphate. The inactive α subunit then dissociates from the effector molecule and re-associates with the βγ complex bringing the system back into the resting condition. 🎞 More videos on Signaling • Cell to Cell Communication:    • Cell to Cell Communication || Types of sig...   • Receptor - Types & Functions:    • Receptors: Types & Functions   • Intracellular Signaling / Second Messenger System:    • Intracellular Signaling / Second Messenger...   ● Follow me at: • Facebook:   / nonstopneuron   • Instagram:   / nonstopneuron   Dr Vipul Navadiya DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.