How a Stanford aging biologist invests in longevity - Dr. Alex Colville скачать в хорошем качестве

How a Stanford aging biologist invests in longevity - Dr. Alex Colville

Alex Colville, PhD, is a Co-founder and General Partner at Age1, one of the premier aging venture capital firms where he has invested in companies like Science, Gordian, Loyal, and General Control. Prior to that, he was an investor and founding chief of staff at Amaranth Foundation, where he invested in moonshot biology and aging initiatives. He got his biotech business career started as a management consultant at Putnam Associates and as a consultant to the Maze Therapeutics BD team and Rubedo Life Sciences R&D team. Alex earned his PhD at Stanford in the biology of aging. 00:00:00 Intro 00:01:18 Did we evolve to age? 00:04:18 Damage repair vs reprogramming approaches to treating aging 00:07:50 Advantage of restore approaches to treating aging 00:09:48 GLP-1s as an aging drug 00:14:35 Evidence for the feasibility of restoring youthfulness 00:26:32 Integrated theories of aging, 00:29:45 Theoretical vs empirical approaches in science 00:35:52 IL-11 and the supermodel granny mouse 00:44:13 Senescence as a target for aging treatment 00:46:41 Epigenetic reprogramming as the holy grail for aging 00:44:13 Retro’s announcement on 50x more effective factors for reprogramming 01:00:25 Timeline to therapies in the clinic 01:02:43 Replacement as an approach to aging 01:09:55 Cryopreservation 01:09:55 Big pharma’s pivot into longevity 01:17:11 Lightning round questions