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Cancer is one of the most feared words in medicine. But it’s not just one disease — it’s more than 100 different diseases, each driven by unique genetic changes. So why is cancer so difficult to cure? And are we closer than ever to changing that? On this episode of Health Matters, Mayo Clinic oncologist Dr. Tanios Bekaii-Saab joins host Kristen Meinzer to explain what cancer really is, how it develops and why it behaves differently from patient to patient — and even from cell to cell. They discuss: • How genetic mutations lead to cancer • The difference between inherited and acquired cancer risk • Why cancer risk increases with age • Why younger adults are being diagnosed more often • How tumors evolve and become resistant to treatment • The role of surgery, chemotherapy and radiation • How immunotherapy “unlocks” the immune system • Whether some cancers can already be cured • Why researchers believe more cures may be possible within the next decade Dr. Bekaii-Saab explains how early-stage cancers can often be cured, how advanced cancers are becoming more treatable and why immunotherapy is one of the most promising frontiers in cancer care. They also explore the importance of screening and prevention — including colonoscopies, mammograms, low-dose CT scans and emerging blood tests that may one day detect cancer even earlier. More than 600,000 Americans die from cancer each year. But survival rates are improving. Research is accelerating. And there is real reason for hope. If you’ve ever wondered whether a cancer cure is possible — or how close we might be — this conversation offers clarity, context and cautious optimism grounded in science. Listen to more Health Matters episodes at: https://mayoclinic.org/healthmatters Subscribe for trusted medical insight, the latest research and practical advice to help you live a healthier life. 0:00 Health Matters intro and episode topic 0:24 Why cancer is so hard 1:25 Meet Dr. Tanios Bakai Saab 1:36 What cancer is, fundamentally 2:24 Inherited vs acquired genetic changes 3:37 Environmental risks and younger cancers 4:32 How aging affects cancer risk 5:00 When mutations escape immune cleanup 6:03 Why cancers vary within one person 6:51 Same cancer, different DNA changes 8:10 Stages, spread, and treatment resistance 8:55 Why cancer type and location matter 9:44 Carcinomas vs sarcomas explained 10:27 Why “colon to bone” isn’t bone cancer 10:38 Why tumors respond differently to treatments 13:26 Is cancer ever “curable”? 16:17 Surgery today and less invasive advances 17:45 Chemotherapy forms and how it works 18:28 Radiation therapy and palliative radiation 20:00 Immunotherapy basics and why it’s tricky 24:16 Future of GI cancer treatments 25:48 Prevention and screening save lives 28:34 Why colonoscopy age dropped to 45 29:05 Blood tests for early detection: what’s coming 30:27 Closing reflections and hope ahead 31:14 Listener voicemail and where to find more From Mayo Clinic to your inbox, sign-up for free: https://mayocl.in/3e71zfi Visit Mayo Clinic: https://mayocl.in/2COVmlm Like Mayo Clinic on Facebook: / mayoclinic Follow Mayo Clinic on Instagram: / mayoclinic Follow Mayo Clinic on X, formerly Twitter: https://x.com/MayoClinic Follow Mayo Clinic on Threads: https://www.threads.net/@mayoclinic