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Hot melt extrusion HME

Hot melt extrusion HME HME is a continuous pharmaceutical process that involves pumping polymeric materials with a rotating screw at temperatures above their glass transition temperature (Tg) and sometimes above the melting temperature (Tm) to achieve molecular level mixing of the active compounds and thermoplastic binders, polymers, or both. This molecular mixing converts the components into an amorphous product with a uniform shape and density, thereby increasing the dissolution profile of the poorly water-soluble drug.