Advancing ADC Development: End-to-End Solutions from Design to Characterisation скачать в хорошем качестве

Advancing ADC Development: End-to-End Solutions from Design to Characterisation

ADC (Antibody-Drug Conjugate) drug discovery is a specialised approach in pharmaceutical research and development that focuses on creating targeted therapies. ADCs combine the targeting ability of monoclonal antibodies with the cell-killing power of cytotoxic drugs. The goal is to deliver a potent drug directly to the target cells while minimising damage to healthy surrounding tissue. Developing an Antibody-Drug Conjugate (ADC) is a complex process that requires careful consideration of several key factors to ensure efficacy, safety, and manufacturability. Here are the main factors that need to be considered, including: • Antibody selection • Cytotoxic drug selection • Linker chemistry • Conjugation chemistry