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#255

Real-Time Conditional Sacral Neuromodulation Using Wireless Bladder Pressure Sensor Majerus S1, Offutt S2, Brink T2, Damaser M3, Zirpel L2 1. Louis Stokes Cleveland VA Medical Center, 2. Medtronic, 3. Cleveland Clinic Lerner Research Institute KEYWORDS: Neuromodulation, New Devices, Pre-Clinical testing, Animal Study Sacral neuromodulation is clinically used for refractory urinary incontinence and generally uses continuous stimulation. Recent studies have indicated conditional SNM, which applies stimulation intermittently, can produce equivalent functional outcome to continuous SNM [1]. Conditional SNM could reduce energy use and is a potential research tool for optimizing SNM use. However, conditional SNM requires feedback on bladder state (pressure or volume) to enable stimulation decisions. This proof-of-concept study was to demonstrate feasibility of automatically triggering SNM using real-time wireless bladder pressure data in urologically normal sheep. Sheep were implanted with Summit™ RC+S, an implantable research stimulator allowing for sub-second control of stimulation through wireless communication. A minimally invasive bladder pressure (MIBP) sensor and a computer algorithm detected the onset of bladder contractions and automatically controlled the Summit device (Figure 1). Continuous and four conditional SNM paradigms were tested over 5 days in four conscious sheep. Read the full abstract text here: https://www.ics.org/2020/abstract/255