Feces body fluid Analysis(Part1)-Bilirubin Metabolism скачать в хорошем качестве

Feces body fluid Analysis(Part1)-Bilirubin Metabolism

Bilirubin originates from breakdown of heme. It is a waste product and the body eliminates it through bile. Biliverdin is first formed from the porphyrin(Pyrrole) part of heme in reticuloendothelial cells and is reduced to bilirubin called unconjugated bilirubin, which is then transported to the liver in association with albumin. This unconjugated bilirubin is insoluble in water. Bilirubin then enters to microsomes of hepatocytes and conjugated by the action of glucuronyl transferase to produce bilirubin monoglucuronide and diglucuronide (conjugated bilirubin). The bilirubin conjugated with glucuronic acid is water soluble and it exerted through bile. The conjugated bilirubin present in bile passes along the bile ducts into the intestine. Here it is reduced by bacterial action and is also deconjugated, mainly in the colon to “urobilinogens.” Urobilinogen is recycled through the body and a part of it is excreted through the urine and in feces. #Urobilin #Stercobililin #stercobilinogen #urobilinogen Reference:https://link.springer.com/chapter/10....