Enhanced lysosomal activity prevents infection with PrPSc and seeding of α-synuclein & tau скачать в хорошем качестве

Enhanced lysosomal activity prevents infection with PrPSc and seeding of α-synuclein & tau

This video summarises the Journal of Biological Chemistry (2025) paper “Enhanced Lysosomal Activity Prevents Infection with PrPSc and the Seeding Activity of α-Synuclein & Tau Prions” (Mercer et al.). Prion diseases spread when misfolded PrPSc proteins evade cellular clearance and template further misfolding. This study reveals that elacridar, a drug originally developed to inhibit drug-efflux transporters, blocks prion infection through an entirely different mechanism: lysosomal activation. The authors show that elacridar accumulates in acidic organelles, upregulates lysosome- and pH-regulating gene programs, and boosts proteolytic activity downstream of the initial PrPC-to-PrPSc conversion event.