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Skin Sensitisation

Dr Kolle introduces data requirements, including the 2016 update to REACH Annex VII, and provides an overview of the key mechanism of skin sensitisation, based on the published adverse outcome pathway. Dr Casati describes the in vitro and in chemico methods that can be used to assess skin sensitisation, with a specific focus on the validated and OECD-adopted methods and on combining them in defined approaches. Dr Kolle provides examples of defined approaches to hazard identification and potency categorisation. Dr Casati closes by reviewing current OECD activities in the field of skin sensitisation.