Biomarkers start telling us a story: Autism pathophysiology revisited скачать в хорошем качестве

Biomarkers start telling us a story: Autism pathophysiology revisited

Learn about emerging research on biomarkers and autism from a recent ARI Research Grant recipient. Free certificates of participation are available upon successful completion of a brief knowledge quiz at: https://autism.org/biomarkers-and-pat... Antonio Persico, MD, studied Psychiatry at the Catholic University of the Sacred Heart (Rome, Italy) in 1990 and worked as Visiting Foreign Fellow at the Natl. Inst. on Drug Abuse (Baltimore, MD) between 1991 and 1994, with a focus on the genetics of drug addiction. Starting in 1995, at University “Campus Bio-Medico” (Rome, Italy), Dr. Persico began exploring the role of serotonin in neurodevelopment and the genetics of autism. Since then, autism and neurodevelopmental disorders have been his primary focus. In 2010, he started the clinical Unit of Child & Adolescent Neuropsychiatry at UCBM, then becoming in 2015 Full Professor of Child and Adolescent Neuropsychiatry at the University of Messina (Italy). Here he directed the Interdepartmental Program “Autism 0-90” at the “G. Martino” University Hospital. Dr. Persico’s overarching target is to “link clinical phenomena to their genetic, epigenetic and neurobiological underpinnings in neurodevelopmental disorders.” His specific research interests are thus primarily translational: clustering autistic patients in biologically meaningful ways, identifying biomarkers for early diagnosis and to predict response/non-response to specific forms of therapies, developing novel evidence-based pharmacological, behavioral and occupational interventions. Dr. Persico’s goal is to “improve as much as possible the long-term trajectory and the quality of life of autistic individuals and their families at all ages.” Currently, Dr. Persico is at Università di Modena e Reggio Emilia. In this webinar: 0:30 – 6:30 – Organization introductions 8:10 – Presentation introduction 12:25 – Genomics 16:00 – Interaction of rare and common gene variants 18:00 – Functional analysis of genetic pathways 21:15 – Neurodevelopmental genes 26:00 – Methylomics 30:00 – Genomic and epigenetic overlap 34:40 – Generational methylation and pathophysiology 41:00 – Transcriptomics 46:30 – Proteomics 50:30 – Metabolomics 55:00 – Functional brain imaging 59:55 – Summary and conclusion 1:03:00 – Q&A