Скачать с ютуб GMO cows use lysostaphin to prevent Staphylococcus infections в хорошем качестве

GMO cows use lysostaphin to prevent Staphylococcus infections

Staphylococcus aureus causes mastitis, a fatal mammary gland infection in cattle costing farmers all over the world millions of dollars annually. Diseased and decreased milk production and inflammation of the animal’s udder accompanies an infection and to date there has been no invention of a vaccine. There are also few successful treatment options with most farmers having to rely on intramammary antibiotics which only have a fifteen percent cure rate and if unsuccessful animals are killed to prevent further spread throughout a farmers heard. But what if there was another option for the treatment of bovine mastitis? Research conducted in 2005 by Dr. Robert Wall and his team found that when lysostaphin, a bacteriocin produced by S. aureus, was intergraded into the milk of cows was able to prevent infection. S. aureus does not only affect cows and if such a treatment option becomes available for them it might one day also be an option for mastitis infections in other livestock or even humans. Creator: Chloe Pullar Description: Hong, S. G., et al. Dogs cloned from fetal fibroblasts by nuclear transfer. Animal Reproduction Science 115, 334-339 (2009). Yu, Q., et al. CRISPR/Cas9-induced targeted mutagenesis and gene replacement to generate long- shelf life tomato lines. Scientific Reports 7 (2017). Campbell, K. H. S., McWhir, J., Ritchie, W. A., & Wilmut, I. Sheep cloned by nuclear transfer from a cultured cell line. Letters to Nature 380, 64-66 (1996). Badiuzzaman, M., Samad, M. A., Siddiki, S. H. M. F., Islam, M. T., & Saha, S. Subclinical mastitis in lactating cows: comparison of four screening tests and effect of animal factors on its occurrence. Bangladesh Society for Veterinary Medicine 13, 41-50 (2015). Breed, R. S., & Brew, J. D. The control of public milk supplies by the use of the microscopic method. Journal of Dairy Science 1 (1917). Kumar, P., et al. Status of subclinical mastitis in crossbred cattle of peri-urban unorganized herd of middle indo-gangetic plains. Indian Journal of Animal Research 55 (2021). Owens, W. E., Watts, J. L., Boddie, R. L., & Nickerson, S. C. Antibiotic treatment of mastitis: comparison of intramammary and intramammary plus intramuscular therapies. Journal of Dairy Science 71, 3143-3147 (1988). Kerr, D. E., et al. Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice. Nature Biotechnology 19, 66–70 (2001). Wall, R. J., et al. Genetically enhanced cows resist intramammary Staphylococcus aureus infection. Nature Biotechnology 23, 445–451 (2005). Baba, T., & Schneewind, O. Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. The EMBO Journal 15, 4789-4797 (1996). Schaffner, W., Melly, M. A., Hash, J. H., & Koenig, M. G. Lysostaphin: an enzymatic approach to staphylococcal disease. Yale Journal of Biology And Medicine 39, 215-229 (1967). Abbasian, S. S., Soufian, S., Ghaznavi-Rad, E., & Abtahi, H. High level activity of recombinant lysostaphin after computer simulation and additive-based refolding. International Journal of Peptide Research and Therapeutics 25, 1241–1249 (2019). Van Hekken, D. L., et al. Fate of lysostaphin in milk from individual cows through pasteurization and cheesemaking. Journal of Dairy Science 92, 444-457 (2009). Jayakumar, J., Kumar, V. A., Biswas, L., & Biswas, R. Therapeutic applications of lysostaphin against Staphylococcus aureus. Journal of Applied Microbiology 131 (2021). Zhao, H., et al. Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing. Science Advances 6 (2020).