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Grandmothers play a key role as alloparents in human families. A leading hypothesis suggests that the inclusive fitness benefits of grandmaternal care selected for an extended female lifespan after reproduction, a unique trait among primates. Beyond lifespan extension, grandmothers may have biological adaptations for caregiving. Research from our lab shows grandmothers have lower DNA methylation of the oxytocin receptor gene (OXTR) compared to non-grandmothers, with lower methylation linked to stronger bonds with grandchildren. MRI scans reveal grandmothers have a lower brain age than controls, further reduced among those with higher engagement. These findings suggest grandmotherhood may enhance oxytocin signaling, promoting bonding and slowing brain aging. Recorded on 02/14/2025. [3/2025] [Show ID: 40383] Donate to UCTV to support informative & inspiring programming: https://www.uctv.tv/donate Learn more about anthropogeny on CARTA's website: https://carta.anthropogeny.org/ More videos from: CARTA: The Origin of Love (https://www.uctv.tv/carta-love) Explore More Humanities on UCTV (https://www.uctv.tv/humanities) The humanities encourage us to think creatively and explore questions about our world. UCTV explores human culture through literature, history, ethics, philosophy, cinema and religion so we can better understand the human experience. Explore More Science & Technology on UCTV (https://www.uctv.tv/science) Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells. UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv)